Role of HLA-DP Expression in Graft-Versus-Host Disease After Unrelated Donor Transplantation

https://ascopubs.org/doi/full/10.1200/JCO.20.00265

CONCLUSION

The level of expression of patient HLA-DPB1 mismatches informs the risk of GVHD after HLA-A, -B, -C, -DRB1, -DQB1–matched unrelated HCT, and the total number of HLA-DPB1 mismatches informs the risk of GVHD after HLA-mismatched unrelated HCT. Prospective consideration of HLA-DPB1 may help to lower GVHD risks after transplantation.